Found 8 hits for monomerid = 346182 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Mus musculus (Mouse)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Rattus norvegicus (Rat)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Rattus norvegicus (Rat)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st... |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM346182
(US10202371, Example 12)Show SMILES COCCOc1ccc(cc1)[C@@H]1OC(=O)N([C@H]1CO)c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N7O6/c1-39-10-11-41-16-4-2-15(3-5-16)21-19(14-37)36(25(38)42-21)20-12-18(32-24(33-20)35-6-8-40-9-7-35)17-13-31-23(30)34-22(17)26(27,28)29/h2-5,12-13,19,21,37H,6-11,14H2,1H3,(H2,30,31,34)/t19-,21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| |
US Patent US10202371 (2019)
BindingDB Entry DOI: 10.7270/Q2KD2123 |
More data for this
Ligand-Target Pair | |
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