BDBM346356 US10202377, Compound 439
SMILES: CS(=O)(=O)NCc1cc(F)cc(c1)-c1cccc2[nH]c(nc12)-c1n[nH]c2cnc(cc12)-c1cncc(CNCc2ccccc2)c1
InChI Key: InChIKey=GXRRFVIHDCISFM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM346356 (US10202377, Compound 439) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Compound Screening: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:2, 11-point d... | US Patent US10202377 (2019) BindingDB Entry DOI: 10.7270/Q2639RV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM346356 (US10202377, Compound 439) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 40.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... | US Patent US10202377 (2019) BindingDB Entry DOI: 10.7270/Q2639RV7 | |||||||||||
More data for this Ligand-Target Pair |