null
SMILES: CCNCc1cncc(c1)-c1cc2c(n[nH]c2cn1)-c1nc2c(cccc2[nH]1)-c1cc(F)cc(NCCN(C)C)c1
InChI Key: InChIKey=RFZNPSAUYNTNKL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM346358 (US10202377, Compound 448) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description Compound Screening: Each compound was dissolved in DMSO as a 10 mM stock and used to prepare compound source plates. Serial dilution (1:2, 11-point d... | US Patent US10202377 (2019) BindingDB Entry DOI: 10.7270/Q2639RV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene Wnt-1 (Homo sapiens (human)) | BDBM346358 (US10202377, Compound 448) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 671 | n/a | n/a | n/a | n/a | n/a | n/a |
Samumed, LLC US Patent | Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col... | US Patent US10202377 (2019) BindingDB Entry DOI: 10.7270/Q2639RV7 | |||||||||||
More data for this Ligand-Target Pair |