null

SMILES: O[C@@H](CC1c2c(cccc2F)-c2cncn12)C12CC3CC(C1)[C@H](O)C(C3)C2

InChI Key: InChIKey=SPKRAWSVCLOAAN-KQQPXENYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347023   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM347023 (US10202388, Compound 23A-3) Show SMILES O[C@@H](CC1c2c(cccc2F)-c2cncn12)C12CC3CC(C1)[C@H](O)C(C3)C2 |r,wU:1.0,wD:22.26,TLB:23:22:19:16.17.21,23:22:16.26.21:19.18.25,1:16:22:19.18.25,THB:17:16:22:19.18.25,17:18:22:16.26.21,26:16:19:22.24.25,26:24:19:16.17.21,(.35,-1.49,;.35,.05,;-.98,.82,;-2.31,.05,;-3.72,.68,;-4.75,-.47,;-6.26,-.15,;-6.73,1.32,;-5.7,2.46,;-4.2,2.14,;-3.17,3.29,;-3.98,-1.8,;-4.14,-3.33,;-2.74,-3.96,;-1.71,-2.81,;-2.48,-1.48,;1.69,.82,;1.69,2.36,;3.01,3.13,;4.35,2.36,;4.35,.82,;3.01,.05,;5.18,-1.08,;6.65,-.61,;3.79,-.43,;3.77,1.97,;2.58,-1.1,)| Show InChI InChI=1S/C22H25FN2O2/c23-16-3-1-2-15-18-10-24-11-25(18)17(20(15)16)6-19(26)22-7-12-4-13(8-22)21(27)14(5-12)9-22/h1-3,10-14,17,19,21,26-27H,4-9H2/t12?,13?,14?,17?,19-,21-,22?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI DE NOVO PHARMATECH CO., LTD. US Patent					Assay Description The TDO2 enzymatic assay was performed by UV absorption using a recombinant TDO2 and L-Tryptophan substrate. The UV absorption signal at 321 nm is co...				US Patent US10202388 (2019) BindingDB Entry DOI: 10.7270/Q2JD4ZXX
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM347023 (US10202388, Compound 23A-3) Show SMILES O[C@@H](CC1c2c(cccc2F)-c2cncn12)C12CC3CC(C1)[C@H](O)C(C3)C2 |r,wU:1.0,wD:22.26,TLB:23:22:19:16.17.21,23:22:16.26.21:19.18.25,1:16:22:19.18.25,THB:17:16:22:19.18.25,17:18:22:16.26.21,26:16:19:22.24.25,26:24:19:16.17.21,(.35,-1.49,;.35,.05,;-.98,.82,;-2.31,.05,;-3.72,.68,;-4.75,-.47,;-6.26,-.15,;-6.73,1.32,;-5.7,2.46,;-4.2,2.14,;-3.17,3.29,;-3.98,-1.8,;-4.14,-3.33,;-2.74,-3.96,;-1.71,-2.81,;-2.48,-1.48,;1.69,.82,;1.69,2.36,;3.01,3.13,;4.35,2.36,;4.35,.82,;3.01,.05,;5.18,-1.08,;6.65,-.61,;3.79,-.43,;3.77,1.97,;2.58,-1.1,)| Show InChI InChI=1S/C22H25FN2O2/c23-16-3-1-2-15-18-10-24-11-25(18)17(20(15)16)6-19(26)22-7-12-4-13(8-22)21(27)14(5-12)9-22/h1-3,10-14,17,19,21,26-27H,4-9H2/t12?,13?,14?,17?,19-,21-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI DE NOVO PHARMATECH CO., LTD. US Patent					Assay Description The compounds described in this disclosure were dissolved in 10% DMSO to predefined concentration. All of the reactions were conducted at room temper...				US Patent US10202388 (2019) BindingDB Entry DOI: 10.7270/Q2JD4ZXX
					More data for this Ligand-Target Pair