BDBM347074 US10202390, Example 29

SMILES: CC(C)(O)CCc1cc(n[nH]1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(cnc12)C#N

InChI Key: InChIKey=PJFHTZQGOQETRA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347074   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM347074 (US10202390, Example 29) Show SMILES CC(C)(O)CCc1cc(n[nH]1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C25H28N8O2/c1-25(2,34)6-3-18-9-23(32-31-18)19-13-27-21(10-22(19)30-17-4-7-35-8-5-17)20-14-29-33-15-16(11-26)12-28-24(20)33/h9-10,12-15,17,34H,3-8H2,1-2H3,(H,27,30)(H,31,32)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description TBD				US Patent US10202390 (2019) BindingDB Entry DOI: 10.7270/Q28W3GDC
					More data for this Ligand-Target Pair