BDBM347129 -(4-(methyl(3-(4-methylpiperazin-1-yl)-4- (2,2,2-trifluoroethoxy)phenyl)amino) phenoxy)pyrido[3,4-d]pyrimidin-4-ol::US10202381, Example 136::US10208039, Example 136

SMILES: CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OCC(F)(F)F)c(c1)N1CCN(C)CC1

InChI Key: InChIKey=JPHIGZVMYOJCPY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347129   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM347129 (-(4-(methyl(3-(4-methylpiperazin-1-yl)-4- (2,2,2-t...) Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OCC(F)(F)F)c(c1)N1CCN(C)CC1 Show InChI InChI=1S/C27H27F3N6O3/c1-34-11-13-36(14-12-34)23-15-19(5-8-24(23)38-17-27(28,29)30)35(2)18-3-6-20(7-4-18)39-26-32-22-16-31-10-9-21(22)25(37)33-26/h3-10,15-16H,11-14,17H2,1-2H3,(H,32,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10208039 (2019) BindingDB Entry DOI: 10.7270/Q241706J
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM347129 (-(4-(methyl(3-(4-methylpiperazin-1-yl)-4- (2,2,2-t...) Show SMILES CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OCC(F)(F)F)c(c1)N1CCN(C)CC1 Show InChI InChI=1S/C27H27F3N6O3/c1-34-11-13-36(14-12-34)23-15-19(5-8-24(23)38-17-27(28,29)30)35(2)18-3-6-20(7-4-18)39-26-32-22-16-31-10-9-21(22)25(37)33-26/h3-10,15-16H,11-14,17H2,1-2H3,(H,32,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ...				US Patent US10202381 (2019) BindingDB Entry DOI: 10.7270/Q2SX6GBM
					More data for this Ligand-Target Pair