BDBM348131 US9790228, Compound 197::US9790228, Compound 50

SMILES: CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12

InChI Key: InChIKey=JVMKLSREJRQYKT-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 348131   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM348131 (US9790228, Compound 197 | US9790228, Compound 50) Show SMILES CN1CCN(CC1)c1nc2ccccc2cc1Cn1nc(-c2cc(O)cc(F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C26H25FN8O/c1-33-6-8-34(9-7-33)25-18(10-16-4-2-3-5-21(16)31-25)14-35-26-22(24(28)29-15-30-26)23(32-35)17-11-19(27)13-20(36)12-17/h2-5,10-13,15,36H,6-9,14H2,1H3,(H2,28,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair