BDBM348153 US9790228, Compound 72

SMILES: CC(c1cc2ccccc2nc1N1CCN(C)CC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12

InChI Key: InChIKey=DKIUSTQYFWCNHL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 348153   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM348153 (US9790228, Compound 72) Show SMILES CC(c1cc2ccccc2nc1N1CCN(C)CC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H28N8O/c1-17(21-15-18-6-3-4-9-22(18)31-26(21)34-12-10-33(2)11-13-34)35-27-23(25(28)29-16-30-27)24(32-35)19-7-5-8-20(36)14-19/h3-9,14-17,36H,10-13H2,1-2H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM348153 (US9790228, Compound 72) Show SMILES CC(c1cc2ccccc2nc1N1CCN(C)CC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H28N8O/c1-17(21-15-18-6-3-4-9-22(18)31-26(21)34-12-10-33(2)11-13-34)35-27-23(25(28)29-16-30-27)24(32-35)19-7-5-8-20(36)14-19/h3-9,14-17,36H,10-13H2,1-2H3,(H2,28,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM348153 (US9790228, Compound 72) Show SMILES CC(c1cc2ccccc2nc1N1CCN(C)CC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H28N8O/c1-17(21-15-18-6-3-4-9-22(18)31-26(21)34-12-10-33(2)11-13-34)35-27-23(25(28)29-16-30-27)24(32-35)19-7-5-8-20(36)14-19/h3-9,14-17,36H,10-13H2,1-2H3,(H2,28,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM348153 (US9790228, Compound 72) Show SMILES CC(c1cc2ccccc2nc1N1CCN(C)CC1)n1nc(-c2cccc(O)c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H28N8O/c1-17(21-15-18-6-3-4-9-22(18)31-26(21)34-12-10-33(2)11-13-34)35-27-23(25(28)29-16-30-27)24(32-35)19-7-5-8-20(36)14-19/h3-9,14-17,36H,10-13H2,1-2H3,(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair