BDBM348210 US9790228, Compound 129

SMILES: Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCOCC2)c2ncnc(N)c12

InChI Key: InChIKey=YFEGYQRVLQBOTK-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 348210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM348210 (US9790228, Compound 129) Show SMILES Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCOCC2)c2ncnc(N)c12 Show InChI InChI=1S/C26H23N9OS/c27-23-21-22(16-5-6-19-20(12-16)37-26(28)32-19)33-35(25(21)30-14-29-23)13-17-11-15-3-1-2-4-18(15)31-24(17)34-7-9-36-10-8-34/h1-6,11-12,14H,7-10,13H2,(H2,28,32)(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM348210 (US9790228, Compound 129) Show SMILES Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCOCC2)c2ncnc(N)c12 Show InChI InChI=1S/C26H23N9OS/c27-23-21-22(16-5-6-19-20(12-16)37-26(28)32-19)33-35(25(21)30-14-29-23)13-17-11-15-3-1-2-4-18(15)31-24(17)34-7-9-36-10-8-34/h1-6,11-12,14H,7-10,13H2,(H2,28,32)(H2,27,29,30)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
PI3-kinase class I (Homo sapiens (Human))	BDBM348210 (US9790228, Compound 129) Show SMILES Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCOCC2)c2ncnc(N)c12 Show InChI InChI=1S/C26H23N9OS/c27-23-21-22(16-5-6-19-20(12-16)37-26(28)32-19)33-35(25(21)30-14-29-23)13-17-11-15-3-1-2-4-18(15)31-24(17)34-7-9-36-10-8-34/h1-6,11-12,14H,7-10,13H2,(H2,28,32)(H2,27,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM348210 (US9790228, Compound 129) Show SMILES Nc1nc2ccc(cc2s1)-c1nn(Cc2cc3ccccc3nc2N2CCOCC2)c2ncnc(N)c12 Show InChI InChI=1S/C26H23N9OS/c27-23-21-22(16-5-6-19-20(12-16)37-26(28)32-19)33-35(25(21)30-14-29-23)13-17-11-15-3-1-2-4-18(15)31-24(17)34-7-9-36-10-8-34/h1-6,11-12,14H,7-10,13H2,(H2,28,32)(H2,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Intellikine LLC US Patent					Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...				US Patent US9790228 (2017) BindingDB Entry DOI: 10.7270/Q26112FV
					More data for this Ligand-Target Pair