BDBM349307 US10207991, Ex. Cpd. No. 4::US10611728, Example Compound 4

SMILES: C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F

InChI Key: InChIKey=PSSRUTSUVLVFTJ-GFCCVEGCSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 349307   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349307 (US10207991, Ex. Cpd. No. 4 | US10611728, Example C...) Show SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F |r| Show InChI InChI=1S/C19H18Cl2F3N/c1-12(2-3-13-4-7-17(20)18(21)8-13)25-10-14-5-6-16(19(22,23)24)9-15(14)11-25/h4-9,12H,2-3,10-11H2,1H3/t12-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair