BDBM349498 1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]-7-(1-methylpyrazol-4-yl)-2,3-dihydroquinoxaline-6-carbonitrile::US10206931, Example 306

SMILES: CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N

InChI Key: InChIKey=CXDDRMUOLXEPGY-AAJMVYRGSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD4 BD1 (aa 42-168) (Homo sapiens (Human))	BDBM349498 (1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...) Show SMILES CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N |r| Show InChI InChI=1S/C24H27N7O/c1-15-9-23(32)29-19-5-4-6-20(24(19)28-15)31-8-7-30(3)21-11-18(17(13-26)14-27-2)16(12-25)10-22(21)31/h4-6,10-11,13-15,26-28H,7-9H2,1-3H3,(H,29,32)/b17-14+,26-13?/t15-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM349498 (1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...) Show SMILES CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N |r| Show InChI InChI=1S/C24H27N7O/c1-15-9-23(32)29-19-5-4-6-20(24(19)28-15)31-8-7-30(3)21-11-18(17(13-26)14-27-2)16(12-25)10-22(21)31/h4-6,10-11,13-15,26-28H,7-9H2,1-3H3,(H,29,32)/b17-14+,26-13?/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair