BDBM349504 (4R)-4-methyl-6-[3-(1-methylpyrazol-1-yl)-8-isoquinolyl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 312

SMILES: CN\C=C(/C=N)c1cc2cccc(-c3cccc4NC(=O)C[C@@H](C)Nc34)c2cn1

InChI Key: InChIKey=GPMVFHQNUQZTJP-DDTSFCPISA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349504   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BRD4 BD1 (aa 42-168) (Homo sapiens (Human))	BDBM349504 ((4R)-4-methyl-6-[3-(1-methylpyrazol-1-yl)-8-isoqui...) Show SMILES CN\C=C(/C=N)c1cc2cccc(-c3cccc4NC(=O)C[C@@H](C)Nc34)c2cn1 |r| Show InChI InChI=1S/C23H23N5O/c1-14-9-22(29)28-20-8-4-7-18(23(20)27-14)17-6-3-5-15-10-21(26-13-19(15)17)16(11-24)12-25-2/h3-8,10-14,24-25,27H,9H2,1-2H3,(H,28,29)/b16-12+,24-11?/t14-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM349504 ((4R)-4-methyl-6-[3-(1-methylpyrazol-1-yl)-8-isoqui...) Show SMILES CN\C=C(/C=N)c1cc2cccc(-c3cccc4NC(=O)C[C@@H](C)Nc34)c2cn1 |r| Show InChI InChI=1S/C23H23N5O/c1-14-9-22(29)28-20-8-4-7-18(23(20)27-14)17-6-3-5-15-10-21(26-13-19(15)17)16(11-24)12-25-2/h3-8,10-14,24-25,27H,9H2,1-2H3,(H,28,29)/b16-12+,24-11?/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US10206931 (2019) BindingDB Entry DOI: 10.7270/Q2GM89FR
					More data for this Ligand-Target Pair