BDBM349506 US10207991, Ex. Cpd. No. 21::US10611728, Example Compound 21

SMILES: C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1

InChI Key: InChIKey=LFYNHAXLOHOWGV-CYBMUJFWSA-N

Data: 6 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 349506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG (Homo sapiens (Human))	BDBM349506 (US10207991, Ex. Cpd. No. 21 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cccc(F)c2C1 |r| Show InChI InChI=1S/C18H19F2N/c1-13(5-6-14-7-9-16(19)10-8-14)21-11-15-3-2-4-18(20)17(15)12-21/h2-4,7-10,13H,5-6,11-12H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair