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SMILES: C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1

InChI Key: InChIKey=WLGVVEQIKFIUPU-CYBMUJFWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 349508   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM349508 (US10207991, Ex. Cpd. No. 23 | US10611728, Example ...) Show SMILES C[C@H](CCc1ccc(F)cc1)N1Cc2cc3OCOc3cc2C1 |r| Show InChI InChI=1S/C19H20FNO2/c1-13(2-3-14-4-6-17(20)7-5-14)21-10-15-8-18-19(23-12-22-18)9-16(15)11-21/h4-9,13H,2-3,10-12H2,1H3/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair