BDBM349518 US10207991, Ex. Cpd. No. 34::US10611728, Example Compound 34
SMILES: COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
InChI Key: InChIKey=FLLIMXCHPPVPAF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si... | US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si... | US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM349518 (US10207991, Ex. Cpd. No. 34 | US10611728, Example ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair |