BDBM349533 US10207991, Ex. Cpd. No. 49::US10611728, Example Compound 49
SMILES: COc1cc(CCC(C)(C)N2Cc3cccc(F)c3C2)ccc1OC(=O)N(C)C
InChI Key: InChIKey=GNOFMAJGHCHTED-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma intracellular receptor 2 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si... | US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si... | US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanin-concentrating hormone receptor 2/HERG (Homo sapiens (Human)) | BDBM349533 (US10207991, Ex. Cpd. No. 49 | US10611728, Example ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
COGNITION THERAPEUTICS, INC. US Patent | Assay Description Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto... | US Patent US10611728 (2020) | |||||||||||
More data for this Ligand-Target Pair |