null

SMILES: CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1

InChI Key: InChIKey=WVWPKPZCILEGOG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 349543   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US9796672 (2017) BindingDB Entry DOI: 10.7270/Q2X92DFN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...				US Patent US10207991 (2019) BindingDB Entry DOI: 10.7270/Q2BV7JRG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM349543 (US10207991, Ex. Cpd. No. 59 | US10611728, Example ...) Show SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 Show InChI InChI=1S/C26H36N2O3/c1-25(2,3)31-23-15-18(11-12-22(23)29)13-14-26(4,5)28-16-19-9-8-10-20(21(19)17-28)24(30)27(6)7/h8-12,15,29H,13-14,16-17H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
COGNITION THERAPEUTICS, INC. US Patent					Assay Description Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...				US Patent US10611728 (2020)
					More data for this Ligand-Target Pair