BDBM350051 US10208024, Example 50::US10766881, Example 50

SMILES: COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1

InChI Key: InChIKey=XNRZJGZKJIEPIW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350051   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...				US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822) (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent									US Patent US10766881 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM350051 (US10208024, Example 50 | US10766881, Example 50) Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...				US Patent US10208024 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GNW
					More data for this Ligand-Target Pair