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SMILES: CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CC(F)(F)F

InChI Key: InChIKey=KMJBSZNZTUBEMD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350222   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C/Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM350222 (US10208056, Compound 53) Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CC(F)(F)F Show InChI InChI=1S/C15H14F3N3O2/c1-14(2)9-5-10(13(19)22)21(7-15(16,17)18)12(9)8-3-4-20-6-11(8)23-14/h3-6H,7H2,1-2H3,(H2,19,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM350222 (US10208056, Compound 53) Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CC(F)(F)F Show InChI InChI=1S/C15H14F3N3O2/c1-14(2)9-5-10(13(19)22)21(7-15(16,17)18)12(9)8-3-4-20-6-11(8)23-14/h3-6H,7H2,1-2H3,(H2,19,22)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.4	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase haspin (Homo sapiens (Human))	BDBM350222 (US10208056, Compound 53) Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CC(F)(F)F Show InChI InChI=1S/C15H14F3N3O2/c1-14(2)9-5-10(13(19)22)21(7-15(16,17)18)12(9)8-3-4-20-6-11(8)23-14/h3-6H,7H2,1-2H3,(H2,19,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair