BDBM350241 US10208056, Compound 68

SMILES: CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC

InChI Key: InChIKey=CEWROMVZNURIEF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK8/Cyclin C (Homo sapiens (Human))	BDBM350241 (US10208056, Compound 68) Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC |(-1.84,4.02,;-2.24,2.53,;-1.15,1.44,;.38,1.6,;1.15,2.93,;2.69,2.93,;.38,4.27,;1.01,.19,;-.14,-.84,;-1.47,-.07,;-2.8,-.84,;-4.14,-.07,;-5.47,-.84,;-5.47,-2.38,;-4.14,-3.15,;-2.8,-2.38,;-1.47,-3.15,;-.14,-2.38,;-.14,-3.92,;1.2,-3.15,;2.5,-.2,;3.58,.88,;5.07,.49,;5.47,-1,;4.38,-2.09,;2.89,-1.69,;1.81,-2.78,;2.2,-4.27,)| Show InChI InChI=1S/C22H23N3O3/c1-5-25-19-14-10-11-24-12-16(14)28-22(2,3)18(19)17(20(25)21(23)26)13-8-6-7-9-15(13)27-4/h6-12H,5H2,1-4H3,(H2,23,26)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.23	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen. This is a kinase assay platform based on measuring the binding and...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair
CDK19/Cyclin C (Homo sapiens (Human))	BDBM350241 (US10208056, Compound 68) Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC |(-1.84,4.02,;-2.24,2.53,;-1.15,1.44,;.38,1.6,;1.15,2.93,;2.69,2.93,;.38,4.27,;1.01,.19,;-.14,-.84,;-1.47,-.07,;-2.8,-.84,;-4.14,-.07,;-5.47,-.84,;-5.47,-2.38,;-4.14,-3.15,;-2.8,-2.38,;-1.47,-3.15,;-.14,-2.38,;-.14,-3.92,;1.2,-3.15,;2.5,-.2,;3.58,.88,;5.07,.49,;5.47,-1,;4.38,-2.09,;2.89,-1.69,;1.81,-2.78,;2.2,-4.27,)| Show InChI InChI=1S/C22H23N3O3/c1-5-25-19-14-10-11-24-12-16(14)28-22(2,3)18(19)17(20(25)21(23)26)13-8-6-7-9-15(13)27-4/h6-12H,5H2,1-4H3,(H2,23,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16.4	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The binding assay relies on the LanthaScreen™ Eu-Kinase Binding Assay (Invitrogen). This is a kinase assay platform based on measuring the binding an...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase haspin (Homo sapiens (Human))	BDBM350241 (US10208056, Compound 68) Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC |(-1.84,4.02,;-2.24,2.53,;-1.15,1.44,;.38,1.6,;1.15,2.93,;2.69,2.93,;.38,4.27,;1.01,.19,;-.14,-.84,;-1.47,-.07,;-2.8,-.84,;-4.14,-.07,;-5.47,-.84,;-5.47,-2.38,;-4.14,-3.15,;-2.8,-2.38,;-1.47,-3.15,;-.14,-2.38,;-.14,-3.92,;1.2,-3.15,;2.5,-.2,;3.58,.88,;5.07,.49,;5.47,-1,;4.38,-2.09,;2.89,-1.69,;1.81,-2.78,;2.2,-4.27,)| Show InChI InChI=1S/C22H23N3O3/c1-5-25-19-14-10-11-24-12-16(14)28-22(2,3)18(19)17(20(25)21(23)26)13-8-6-7-9-15(13)27-4/h6-12H,5H2,1-4H3,(H2,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	354	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F.S.P. CNIO) US Patent					Assay Description The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...				US Patent US10208056 (2019) BindingDB Entry DOI: 10.7270/Q2GB266B
					More data for this Ligand-Target Pair