BDBM350334 (S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-7-fluoroisoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one::US10307414, Example 18::US9801872, Example 18

SMILES: Fc1ccc2cc(nc(O[C@H]3CCN(C3)C(=O)C=C)c2c1)-c1n[nH]c(=O)[nH]1

InChI Key: InChIKey=VGSJJEMBUYYXIE-LBPRGKRZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350334   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM350334 ((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-7-fluoro...) Show SMILES Fc1ccc2cc(nc(O[C@H]3CCN(C3)C(=O)C=C)c2c1)-c1n[nH]c(=O)[nH]1 |r| Show InChI InChI=1S/C18H14FN5O3/c1-2-15(25)24-6-5-12(9-24)27-17-13-8-11(19)4-3-10(13)7-14(20-17)16-21-18(26)23-22-16/h2-4,7-8,12H,1,5-6,9H2/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<6.31	n/a	n/a	n/a	n/a	n/a	n/a
CNRS					Assay Description The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...				Bioorg Med Chem Lett 19: 1600-3 (2009) BindingDB Entry DOI: 10.7270/Q2TQ63WG
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM350334 ((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-7-fluoro...) Show SMILES Fc1ccc2cc(nc(O[C@H]3CCN(C3)C(=O)C=C)c2c1)-c1n[nH]c(=O)[nH]1 |r| Show InChI InChI=1S/C18H14FN5O3/c1-2-15(25)24-6-5-12(9-24)27-17-13-8-11(19)4-3-10(13)7-14(20-17)16-21-18(26)23-22-16/h2-4,7-8,12H,1,5-6,9H2/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<6.31	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...				US Patent US9801872 (2017) BindingDB Entry DOI: 10.7270/Q2BC41PD
					More data for this Ligand-Target Pair