BDBM350371 US9802904, 22

SMILES: FC(F)(F)c1cc(ccc1Cl)-c1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1

InChI Key: InChIKey=LYPFXOGRMGPMCT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350371   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
USP1/UAF1 (Homo sapiens (Human))	BDBM350371 (US9802904, 22) Show SMILES FC(F)(F)c1cc(ccc1Cl)-c1ccc(CNc2cccc3nc(ncc23)-c2ccccc2C(F)(F)F)cc1 Show InChI InChI=1S/C29H18ClF6N3/c30-24-13-12-19(14-23(24)29(34,35)36)18-10-8-17(9-11-18)15-37-25-6-3-7-26-21(25)16-38-27(39-26)20-4-1-2-5-22(20)28(31,32)33/h1-14,16,37H,15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware US Patent					Assay Description This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...				US Patent US9802904 (2017) BindingDB Entry DOI: 10.7270/Q2TF00H8
					More data for this Ligand-Target Pair