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SMILES: CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2nc[nH]c2n1

InChI Key: InChIKey=TUIDXAHRMLQEII-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350378   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48


(Homo sapiens (Human))		BDBM350378
PNG
(US9802904, 52)
Show SMILES CC(C)c1ccccc1-c1nc(NCc2ccc(cc2)-c2ccccc2)c2nc[nH]c2n1
Show InChI InChI=1S/C27H25N5/c1-18(2)22-10-6-7-11-23(22)25-31-26(24-27(32-25)30-17-29-24)28-16-19-12-14-21(15-13-19)20-8-4-3-5-9-20/h3-15,17-18H,16H2,1-2H3,(H2,28,29,30,31,32)
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US Patent
n/an/a 240n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...

US Patent US9802904 (2017)


BindingDB Entry DOI: 10.7270/Q2TF00H8
More data for this
Ligand-Target Pair