null
SMILES: C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1
InChI Key: InChIKey=WKDBRCUUDXLTIM-NSHDSACASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u... | US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u... | US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u... | US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u... | US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His-tagged full length human PI3Kgamma expressed in baculovirus expression system after 80 mins by fluorescence ... | J Med Chem 62: 4783-4814 (2019) Article DOI: 10.1021/acs.jmedchem.8b01298 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit alpha (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 272 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus... | J Med Chem 62: 4783-4814 (2019) Article DOI: 10.1021/acs.jmedchem.8b01298 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human)) | BDBM350391 ((S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
HUTCHISON MEDIPHARMA LIMITED US Patent | Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi... | US Patent US10611777 (2020) | |||||||||||
More data for this Ligand-Target Pair |