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SMILES: C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1

InChI Key: InChIKey=RWTMOOSKONUPBV-NSHDSACASA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 350454   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM350454 ((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...				US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM350454 ((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	712	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...				US Patent US10611777 (2020) BindingDB Entry DOI: 10.7270/Q26113BX
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM350454 ((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...				US Patent US10611777 (2020) BindingDB Entry DOI: 10.7270/Q26113BX
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM350454 ((S)-4-amino-6-(0-(3-fluoro-6-phenylimidazo[1,2-b]p...) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(F)n2nc1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	712	n/a	n/a	n/a	n/a	n/a	n/a
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...				US Patent US10208066 (2019) BindingDB Entry DOI: 10.7270/Q2319Z0W
					More data for this Ligand-Target Pair