BDBM35053 K00486

SMILES: CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1

InChI Key: InChIKey=KWWMCDVDRSJVAC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM35053 (K00486) Show SMILES CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1 Show InChI InChI=1S/C16H16ClFN4O/c1-2-11(9-23)20-15-5-6-16-19-8-14(22(16)21-15)10-3-4-13(18)12(17)7-10/h3-8,11,23H,2,9H2,1H3,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	25
University Hospital Basel					Assay Description Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...				Cancer Res 67: 6916-24 (2007) Article DOI: 10.1158/0008-5472.CAN-07-0320 BindingDB Entry DOI: 10.7270/Q23X850Z
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM35053 (K00486) Show SMILES CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1 Show InChI InChI=1S/C16H16ClFN4O/c1-2-11(9-23)20-15-5-6-16-19-8-14(22(16)21-15)10-3-4-13(18)12(17)7-10/h3-8,11,23H,2,9H2,1H3,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.5	25
University Hospital Basel					Assay Description Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...				Cancer Res 67: 6916-24 (2007) Article DOI: 10.1158/0008-5472.CAN-07-0320 BindingDB Entry DOI: 10.7270/Q23X850Z
					More data for this Ligand-Target Pair