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SMILES: NC(=O)C1CCCC(C1)Nc1ncc(c(Nc2ccc(F)cc2NC(=O)C=C)n1)C(F)(F)F

InChI Key: InChIKey=IKSLVHOCBRNZDF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350911   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 3


(Homo sapiens (Human))		BDBM350911
PNG
(US9796700, Compound I-5)
Show SMILES NC(=O)C1CCCC(C1)Nc1ncc(c(Nc2ccc(F)cc2NC(=O)C=C)n1)C(F)(F)F
Show InChI InChI=1S/C21H22F4N6O2/c1-2-17(32)29-16-9-12(22)6-7-15(16)30-19-14(21(23,24)25)10-27-20(31-19)28-13-5-3-4-11(8-13)18(26)33/h2,6-7,9-11,13H,1,3-5,8H2,(H2,26,33)(H,29,32)(H2,27,28,30,31)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC

US Patent


Assay Description
The protocol below describes continuous-read kinase assays to measure potency of compounds against activated ERK1 enzyme. The mechanics of the assay ...

US Patent US9796700 (2017)


BindingDB Entry DOI: 10.7270/Q2J38VQD
More data for this
Ligand-Target Pair