BDBM352012 US9802904, 73

SMILES: CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccnc(c2)C(F)(F)F)n1

InChI Key: InChIKey=PXQNHGBUVHKIMI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 352012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 (Homo sapiens (Human))	BDBM352012 (US9802904, 73) Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccnc(c2)C(F)(F)F)n1 Show InChI InChI=1S/C27H25F3N4/c1-17(2)22-6-4-5-7-23(22)26-32-15-18(3)25(34-26)33-16-19-8-10-20(11-9-19)21-12-13-31-24(14-21)27(28,29)30/h4-15,17H,16H2,1-3H3,(H,32,33,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
National Center for Advancing Translational Sciences Curated by ChEMBL					Assay Description Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assay				J Med Chem 57: 8099-110 (2014) Article DOI: 10.1021/jm5010495 BindingDB Entry DOI: 10.7270/Q24X5BSH
					More data for this Ligand-Target Pair
USP1/UAF1 (Homo sapiens (Human))	BDBM352012 (US9802904, 73) Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-c2ccnc(c2)C(F)(F)F)n1 Show InChI InChI=1S/C27H25F3N4/c1-17(2)22-6-4-5-7-23(22)26-32-15-18(3)25(34-26)33-16-19-8-10-20(11-9-19)21-12-13-31-24(14-21)27(28,29)30/h4-15,17H,16H2,1-3H3,(H,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware US Patent					Assay Description This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...				US Patent US9802904 (2017) BindingDB Entry DOI: 10.7270/Q2TF00H8
					More data for this Ligand-Target Pair