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SMILES: CC(C)c1ccccc1-c1ncc(C)c(NC2(CC2)c2ccc(cc2)-c2cccnc2)n1

InChI Key: InChIKey=JACYUDVUPWGGPQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 352028   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48


(Homo sapiens (Human))		BDBM352028
PNG
(US9802904, 89)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NC2(CC2)c2ccc(cc2)-c2cccnc2)n1
Show InChI InChI=1S/C28H28N4/c1-19(2)24-8-4-5-9-25(24)27-30-17-20(3)26(31-27)32-28(14-15-28)23-12-10-21(11-13-23)22-7-6-16-29-18-22/h4-13,16-19H,14-15H2,1-3H3,(H,30,31,32)
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US Patent
n/an/a 34n/an/an/an/an/an/a



The United States of America, as represented by the Secretary, Department of Health and Human Services; University of Delaware

US Patent


Assay Description
This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...

US Patent US9802904 (2017)


BindingDB Entry DOI: 10.7270/Q2TF00H8
More data for this
Ligand-Target Pair