BDBM3540 4-N-(3-bromophenyl)-7-N-methylquinazoline-4,7-diamine::4-[(3-Bromophenyl)amino]-7-(methylamino)quinazoline::CHEMBL92812::PD153035 Analog::PD153035 Analog 40

SMILES: CNc1ccc2c(Nc3cccc(Br)c3)ncnc2c1

InChI Key: InChIKey=NJCGPPRBJLJTPA-UHFFFAOYSA-N

Data: 3 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3540   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3540 (4-N-(3-bromophenyl)-7-N-methylquinazoline-4,7-diam...) Show SMILES CNc1ccc2c(Nc3cccc(Br)c3)ncnc2c1 Show InChI InChI=1S/C15H13BrN4/c1-17-11-5-6-13-14(8-11)18-9-19-15(13)20-12-4-2-3-10(16)7-12/h2-9,17H,1H3,(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 39: 267-76 (1996) Article DOI: 10.1021/jm9503613 BindingDB Entry DOI: 10.7270/Q25T3HPR
					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM3540 (4-N-(3-bromophenyl)-7-N-methylquinazoline-4,7-diam...) Show SMILES CNc1ccc2c(Nc3cccc(Br)c3)ncnc2c1 Show InChI InChI=1S/C15H13BrN4/c1-17-11-5-6-13-14(8-11)18-9-19-15(13)20-12-4-2-3-10(16)7-12/h2-9,17H,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Protana Inc. Curated by ChEMBL					Assay Description Inhibition of EPH receptor B2 using ELISA				J Med Chem 48: 3221-30 (2005) Article DOI: 10.1021/jm0492204 BindingDB Entry DOI: 10.7270/Q2DF6QRN
					More data for this Ligand-Target Pair
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM3540 (4-N-(3-bromophenyl)-7-N-methylquinazoline-4,7-diam...) Show SMILES CNc1ccc2c(Nc3cccc(Br)c3)ncnc2c1 Show InChI InChI=1S/C15H13BrN4/c1-17-11-5-6-13-14(8-11)18-9-19-15(13)20-12-4-2-3-10(16)7-12/h2-9,17H,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.19E+4	n/a	n/a	n/a	n/a	n/a
Protana Inc. Curated by ChEMBL					Assay Description Equilibrium binding constant for EPH receptor B2				J Med Chem 48: 3221-30 (2005) Article DOI: 10.1021/jm0492204 BindingDB Entry DOI: 10.7270/Q2DF6QRN
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3540 (4-N-(3-bromophenyl)-7-N-methylquinazoline-4,7-diam...) Show SMILES CNc1ccc2c(Nc3cccc(Br)c3)ncnc2c1 Show InChI InChI=1S/C15H13BrN4/c1-17-11-5-6-13-14(8-11)18-9-19-15(13)20-12-4-2-3-10(16)7-12/h2-9,17H,1H3,(H,18,19,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Zurich Curated by ChEMBL					Assay Description Inhibition of EGFR				J Med Chem 51: 1179-88 (2008) Article DOI: 10.1021/jm070654j BindingDB Entry DOI: 10.7270/Q29Z95RD
					More data for this Ligand-Target Pair