BDBM354597 2-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxyphenyl) (methyl)carbamoyl]-1,5-dimethyl-1H-pyrrol-2-yl}-7-[(3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate::US9809574, Example 392

SMILES: C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2CN(CCc2cc1-c1cc(C(=O)N(C)c2ccc(O)cc2)c(C)n1C)C(=O)Oc1ccccc1OCCN(C)C

InChI Key: InChIKey=XNLSIOIZNAFTBH-GDLZYMKVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM354597 (2-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...) Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2CN(CCc2cc1-c1cc(C(=O)N(C)c2ccc(O)cc2)c(C)n1C)C(=O)Oc1ccccc1OCCN(C)C Show InChI InChI=1S/C45H49N5O6/c1-29-23-31-11-7-8-12-33(31)28-50(29)44(53)39-25-34-27-49(45(54)56-42-14-10-9-13-41(42)55-22-21-46(3)4)20-19-32(34)24-38(39)40-26-37(30(2)47(40)5)43(52)48(6)35-15-17-36(51)18-16-35/h7-18,24-26,29,51H,19-23,27-28H2,1-6H3/t29-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...				US Patent US9809574 (2017) BindingDB Entry DOI: 10.7270/Q2MP55DF
					More data for this Ligand-Target Pair