BDBM354697 Preparation of 4-((2R,5R)-5-((4-cyanophenoxy)methyl)-2-(trifluoromethyl)oxazolidin-3-yl)-2-(trifluoromethyl)benzonitrile::US9809583, Example 5

SMILES: Cc1cc(ccc1[N+]([O-])=O)N1C[C@@H](COc2ccc(cc2)C#N)O[C@@H]1C(F)(F)F

InChI Key: InChIKey=HMTTYVGJJVFZAE-FUHWJXTLSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Androgen receptor (Chlorocebus sabaeus (Green monkey) (Cercopithecus ...)	BDBM354697 (Preparation of 4-((2R,5R)-5-((4-cyanophenoxy)methy...) Show SMILES Cc1cc(ccc1[N+]([O-])=O)N1C[C@@H](COc2ccc(cc2)C#N)O[C@@H]1C(F)(F)F |r| Show InChI InChI=1S/C19H16F3N3O4/c1-12-8-14(4-7-17(12)25(26)27)24-10-16(29-18(24)19(20,21)22)11-28-15-5-2-13(9-23)3-6-15/h2-8,16,18H,10-11H2,1H3/t16-,18+/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91.6	n/a	n/a	n/a	n/a	n/a	n/a
DONG-A ST CO., LTD. US Patent					Assay Description In order to examine binding ability of the agonists of the present invention to androgen receptors, the following in-vitro experiment was performed. ...				US Patent US9809583 (2017) BindingDB Entry DOI: 10.7270/Q2C82CGC
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