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BDBM354712 Preparation of N-(4-(((2R,5S)-3-(4-cyano-3-(trifluoromethyl)phenyl)-2-(trifluoromethyl)oxazolidin-5-yl)methoxy)phenyl)acetamide::US9809583, Example 25

SMILES: CC(=O)Nc1ccc(OC[C@@H]2CN([C@H](O2)C(F)(F)F)c2ccc(C#N)c(c2)C(F)(F)F)cc1

InChI Key: InChIKey=ARNMYXIBHMJEMH-PKOBYXMFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354712   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Androgen Receptor


(Chlorocebus sabaeus (Green monkey) (Cercopithecus ...)		BDBM354712
PNG
(Preparation of N-(4-(((2R,5S)-3-(4-cyano-3-(triflu...)
Show SMILES CC(=O)Nc1ccc(OC[C@@H]2CN([C@H](O2)C(F)(F)F)c2ccc(C#N)c(c2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C21H17F6N3O3/c1-12(31)29-14-3-6-16(7-4-14)32-11-17-10-30(19(33-17)21(25,26)27)15-5-2-13(9-28)18(8-15)20(22,23)24/h2-8,17,19H,10-11H2,1H3,(H,29,31)/t17-,19+/m0/s1
PDB

UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a 8.5n/an/an/an/an/an/a



DONG-A ST CO., LTD.

US Patent


Assay Description
In order to examine binding ability of the agonists of the present invention to androgen receptors, the following in-vitro experiment was performed. ...

US Patent US9809583 (2017)


BindingDB Entry DOI: 10.7270/Q2C82CGC
More data for this
Ligand-Target Pair