BDBM354761 Preparation of 4-(7-(1H-indol-5-yl)-5H-pyrrolo[3,2-b]pyrazin-2-yl)-2-methoxyaniline ::US10485800, Example 38::US9814704, Example 38

SMILES: COc1cc(ccc1N)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1

InChI Key: InChIKey=OXKSBVDGXACCCO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354761 (Preparation of 4-(7-(1H-indol-5-yl)-5H-pyrrolo[3,2...) Show SMILES COc1cc(ccc1N)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C21H17N5O/c1-27-19-9-13(2-4-16(19)22)18-11-25-21-20(26-18)15(10-24-21)12-3-5-17-14(8-12)6-7-23-17/h2-11,23H,22H2,1H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester; Board of Regents of the University of Nebraska US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US10485800 (2019) BindingDB Entry DOI: 10.7270/Q22B91DW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Homo sapiens (Human))	BDBM354761 (Preparation of 4-(7-(1H-indol-5-yl)-5H-pyrrolo[3,2...) Show SMILES COc1cc(ccc1N)-c1cnc2[nH]cc(-c3ccc4[nH]ccc4c3)c2n1 Show InChI InChI=1S/C21H17N5O/c1-27-19-9-13(2-4-16(19)22)18-11-25-21-20(26-18)15(10-24-21)12-3-5-17-14(8-12)6-7-23-17/h2-11,23H,22H2,1H3,(H,24,25)	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The University of Rochester US Patent					Assay Description 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...				US Patent US9814704 (2017) BindingDB Entry DOI: 10.7270/Q27H1MRN
					More data for this Ligand-Target Pair