BDBM355418 N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)phenyl]propyl}- 2-(3-fluoro-4-methoxybenzyl)-6- oxo-1,6-dihydropyrimidine-4- carboxamide::US9815796, Example 509
SMILES: COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1F
InChI Key:
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM355418 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM355418 (N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethoxy)pheny...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ | |||||||||||
More data for this Ligand-Target Pair |