BDBM355552 N-{(1S)-1-[2-chloro-4- (trifluoromethyl)phenyl]-2-hydroxy- 1-methylethyl}-6-oxo-2-phenyl-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 643
SMILES: C[C@](CO)(NC(=O)c1cc(=O)[nH]c(n1)-c1ccccc1)c1ccc(cc1Cl)C(F)(F)F
InChI Key:
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM355552 (N-{(1S)-1-[2-chloro-4- (trifluoromethyl)phenyl]-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; MSD R & D (China) Co. LTD. US Patent | Assay Description In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi... | US Patent US9815796 (2017) BindingDB Entry DOI: 10.7270/Q2V69MQQ | |||||||||||
More data for this Ligand-Target Pair |