BDBM355727 US9815820, Y-27263

SMILES: CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1

InChI Key: InChIKey=ZOJWMHJRZRKSRN-JOCQHMNTSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 355727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM355727 (US9815820, Y-27263) Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,(-5.43,-.71,;-4.66,.62,;-5.43,1.96,;-3.12,.62,;-2.35,-.71,;-.81,-.71,;-.04,.62,;-.81,1.96,;-2.35,1.96,;1.5,.62,;2.27,-.71,;2.27,1.96,;3.81,1.96,;4.58,.62,;6.12,.62,;6.89,1.96,;6.12,3.29,;4.58,3.29,)| Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM355727 (US9815820, Y-27263) Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,(-5.43,-.71,;-4.66,.62,;-5.43,1.96,;-3.12,.62,;-2.35,-.71,;-.81,-.71,;-.04,.62,;-.81,1.96,;-2.35,1.96,;1.5,.62,;2.27,-.71,;2.27,1.96,;3.81,1.96,;4.58,.62,;6.12,.62,;6.89,1.96,;6.12,3.29,;4.58,3.29,)| Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM355727 (US9815820, Y-27263) Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,(-5.43,-.71,;-4.66,.62,;-5.43,1.96,;-3.12,.62,;-2.35,-.71,;-.81,-.71,;-.04,.62,;-.81,1.96,;-2.35,1.96,;1.5,.62,;2.27,-.71,;2.27,1.96,;3.81,1.96,;4.58,.62,;6.12,.62,;6.89,1.96,;6.12,3.29,;4.58,3.29,)| Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM355727 (US9815820, Y-27263) Show SMILES CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,(-5.43,-.71,;-4.66,.62,;-5.43,1.96,;-3.12,.62,;-2.35,-.71,;-.81,-.71,;-.04,.62,;-.81,1.96,;-2.35,1.96,;1.5,.62,;2.27,-.71,;2.27,1.96,;3.81,1.96,;4.58,.62,;6.12,.62,;6.89,1.96,;6.12,3.29,;4.58,3.29,)| Show InChI InChI=1S/C15H22N2O/c1-11(2)12-3-5-13(6-4-12)15(18)17-14-7-9-16-10-8-14/h7-13H,3-6H2,1-2H3,(H,16,17,18)/t12-,13-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	1.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kadmon Corporation, LLC US Patent					Assay Description Kinase inhibition can be determined using an IMAP® assay (Molecular Devices). This assay method involves the use of a fluorescently-tagged peptide su...				US Patent US9815820 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TP0
					More data for this Ligand-Target Pair