BDBM35582 pyrazolo pyrimidine, 15

SMILES: CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(C)=O)c2n1

InChI Key: InChIKey=NNYPLMSOAFZNTE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35582   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110α/p85α (Homo sapiens (Human))	BDBM35582 (pyrazolo pyrimidine, 15) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(C)=O)c2n1 Show InChI InChI=1S/C24H30N8O3/c1-16(33)30-9-7-19(8-10-30)32-23-20(15-26-32)22(31-11-13-35-14-12-31)28-21(29-23)17-3-5-18(6-4-17)27-24(34)25-2/h3-6,15,19H,7-14H2,1-2H3,(H2,25,27,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	25
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 52: 5013-6 (2009) Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM35582 (pyrazolo pyrimidine, 15) Show SMILES CNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(C)=O)c2n1 Show InChI InChI=1S/C24H30N8O3/c1-16(33)30-9-7-19(8-10-30)32-23-20(15-26-32)22(31-11-13-35-14-12-31)28-21(29-23)17-3-5-18(6-4-17)27-24(34)25-2/h3-6,15,19H,7-14H2,1-2H3,(H2,25,27,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.4	23
Wyeth Research					Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...				J Med Chem 52: 5013-6 (2009) Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD
					More data for this Ligand-Target Pair