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SMILES: CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnn3ccc(-c4cccc(CN5CCOCC5)c4)c23)c(F)c1

InChI Key: InChIKey=YIJCVVGDPBPLPN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355859   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM355859
PNG
(4-ethoxy-N-(3-fluoro-4-((5-(pyrimidin-5-yl)pyrrolo...)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnn3ccc(-c4cccc(CN5CCOCC5)c4)c23)c(F)c1
Show InChI InChI=1S/C38H33F2N5O5/c1-2-49-33-14-16-44(29-9-6-27(39)7-10-29)38(47)35(33)37(46)42-28-8-11-32(31(40)23-28)50-34-12-15-41-45-17-13-30(36(34)45)26-5-3-4-25(22-26)24-43-18-20-48-21-19-43/h3-17,22-23H,2,18-21,24H2,1H3,(H,42,46)
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US Patent
n/an/a<40n/an/an/an/an/an/a



The Asan Foundation

US Patent


Assay Description
The inhibitory effect of the compounds of the present invention on the activity of c-Met was confirmed as follows.Specifically, 250 μM G4Y1 pept...

US Patent US9815840 (2017)


BindingDB Entry DOI: 10.7270/Q2862JQZ
More data for this
Ligand-Target Pair