BDBM35586 pyrazolo pyrimidine, 26
SMILES: O=C(Nc1ccncc1)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3cccnc3)c2n1
InChI Key: InChIKey=HLHOHTNONYACFD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p110α/p85α (Homo sapiens (Human)) | BDBM35586 (pyrazolo pyrimidine, 26) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 548 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research | Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. | J Med Chem 52: 5013-6 (2009) Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM35586 (pyrazolo pyrimidine, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research | Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... | J Med Chem 52: 5013-6 (2009) Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD | |||||||||||
More data for this Ligand-Target Pair |