BDBM355871 N-(4-((5-(3-amino-2-methyl)-5-fluorophenyl)pyrrolo[1,2-b]pyridazin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide::US9815840, Example 79

SMILES: Cc1c(N)cccc1-c1ccn2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12

InChI Key: InChIKey=HYGBRBKZFSUQEB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM355871 (N-(4-((5-(3-amino-2-methyl)-5-fluorophenyl)pyrrolo...) Show SMILES Cc1c(N)cccc1-c1ccn2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12 Show InChI InChI=1S/C31H25F2N5O3/c1-18-22(3-2-4-25(18)34)23-12-16-38-28(23)27(11-15-35-38)41-26-10-9-21(17-24(26)33)37-30(40)31(13-14-31)29(39)36-20-7-5-19(32)6-8-20/h2-12,15-17H,13-14,34H2,1H3,(H,36,39)(H,37,40)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
The Asan Foundation US Patent					Assay Description The inhibitory effect of the compounds of the present invention on the activity of c-Met was confirmed as follows.Specifically, 250 μM G4Y1 pept...				US Patent US9815840 (2017) BindingDB Entry DOI: 10.7270/Q2862JQZ
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