Found 4 hits for monomerid = 35589 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35589
(pyrazolo pyrimidine, 21)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1 Show InChI InChI=1S/C25H32N8O4/c1-3-26-24(34)28-18-6-4-17(5-7-18)21-29-22(31-12-14-37-15-13-31)20-16-27-33(23(20)30-21)19-8-10-32(11-9-19)25(35)36-2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,26,28,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 5013-6 (2009)
Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35589
(pyrazolo pyrimidine, 21)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1 Show InChI InChI=1S/C25H32N8O4/c1-3-26-24(34)28-18-6-4-17(5-7-18)21-29-22(31-12-14-37-15-13-31)20-16-27-33(23(20)30-21)19-8-10-32(11-9-19)25(35)36-2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,26,28,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha |
J Med Chem 52: 7942-5 (2009)
Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35589
(pyrazolo pyrimidine, 21)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1 Show InChI InChI=1S/C25H32N8O4/c1-3-26-24(34)28-18-6-4-17(5-7-18)21-29-22(31-12-14-37-15-13-31)20-16-27-33(23(20)30-21)19-8-10-32(11-9-19)25(35)36-2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,26,28,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of Flag-tagged human mTOR by DELFIA method |
J Med Chem 52: 7942-5 (2009)
Article DOI: 10.1021/jm901415x BindingDB Entry DOI: 10.7270/Q2WM1DGH |
More data for this Ligand-Target Pair | |
p110α/p85α
(Homo sapiens (Human)) | BDBM35589
(pyrazolo pyrimidine, 21)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1 Show InChI InChI=1S/C25H32N8O4/c1-3-26-24(34)28-18-6-4-17(5-7-18)21-29-22(31-12-14-37-15-13-31)20-16-27-33(23(20)30-21)19-8-10-32(11-9-19)25(35)36-2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,26,28,34) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 5013-6 (2009)
Article DOI: 10.1021/jm900851f BindingDB Entry DOI: 10.7270/Q2SJ1HZD |
More data for this Ligand-Target Pair | |