BDBM355899 1-(4-(2- aminopyrimidin-4- yl)-3-chlorophenyl)- 3-(2-chloro-7- isopropylpyrazolo[1, 5-a]pyrimidin-6- yl)urea::US9815842, Example 23

SMILES: CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-c2ccnc(N)n2)cnc2cc(Cl)nn12

InChI Key: InChIKey=RJNVCKHFDBAILB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 355899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM355899 (1-(4-(2- aminopyrimidin-4- yl)-3-chlorophenyl)- 3-...) Show SMILES CC(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-c2ccnc(N)n2)cnc2cc(Cl)nn12 Show InChI InChI=1S/C19H17Cl2N9O/c1-9(2)17-13(8-24-15-6-14(21)29-30(15)17)28-19(31)26-10-5-11(20)16(25-7-10)12-3-4-23-18(22)27-12/h3-9H,1-2H3,(H2,22,23,27)(H2,26,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair