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SMILES: CC(C)(C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
InChI Key: InChIKey=OJKLPTOCIAYTAS-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824] (Homo sapiens (Human)) | BDBM355910 (1-(7-(tert-butyl)-2- chloropyrazolo[1,5- a]pyrimid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state... | US Patent US10442808 (2019) BindingDB Entry DOI: 10.7270/Q2S75JQ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human)) | BDBM355910 (1-(7-(tert-butyl)-2- chloropyrazolo[1,5- a]pyrimid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ... | US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
