BDBM355914 1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7- cyclobutylpyrazolo[1, 5-a]pyrimidin-6- yl)urea::US10442808, Example 38::US9815842, Example 38

SMILES: Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCC3)n2n1

InChI Key: InChIKey=YVOLOBRFMOPWJB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355914   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824) (Homo sapiens (Human))	BDBM355914 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCC3)n2n1 Show InChI InChI=1S/C18H15Cl2N9O/c19-12-6-11(8-22-17(12)29-23-4-5-24-29)25-18(30)26-13-9-21-15-7-14(20)27-28(15)16(13)10-2-1-3-10/h4-10H,1-3H2,(H2,25,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...				US Patent US10442808 (2019) BindingDB Entry DOI: 10.7270/Q2S75JQ3
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM355914 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCC3)n2n1 Show InChI InChI=1S/C18H15Cl2N9O/c19-12-6-11(8-22-17(12)29-23-4-5-24-29)25-18(30)26-13-9-21-15-7-14(20)27-28(15)16(13)10-2-1-3-10/h4-10H,1-3H2,(H2,25,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair