BDBM355928 1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7- cyclopropylpyrazolo [1,5-a]pyrimidin-6- yl)urea::US10442808, Example 52::US9815842, Example 52

SMILES: Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1

InChI Key: InChIKey=MHTDDROMURWUNV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355928   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824) (Homo sapiens (Human))	BDBM355928 (1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1 Show InChI InChI=1S/C17H13Cl2N9O/c18-11-5-10(7-21-16(11)28-22-3-4-23-28)24-17(29)25-12-8-20-14-6-13(19)26-27(14)15(12)9-1-2-9/h3-9H,1-2H2,(H2,24,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...				US Patent US10442808 (2019) BindingDB Entry DOI: 10.7270/Q2S75JQ3
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM355928 (1-(4-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CC3)n2n1 Show InChI InChI=1S/C17H13Cl2N9O/c18-11-5-10(7-21-16(11)28-22-3-4-23-28)24-17(29)25-12-8-20-14-6-13(19)26-27(14)15(12)9-1-2-9/h3-9H,1-2H2,(H2,24,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair