BDBM355951 (S)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra- zolo[1,5-a]pyrimidin- 6-yl)-3-(2- (trifluoromethyl)pyri- din-4-yl)urea::US10442808, Example 75::US9815842, Example 75

SMILES: CO[C@@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12

InChI Key: InChIKey=RCOAOGBCUNIRLJ-INIZCTEOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355951   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)(aa 329-824) (Homo sapiens (Human))	BDBM355951 ((S)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra...) Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H18ClF3N6O2/c1-9(2)16(30-3)15-11(8-24-14-7-13(19)27-28(14)15)26-17(29)25-10-4-5-23-12(6-10)18(20,21)22/h4-9,16H,1-3H3,(H2,23,25,26,29)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...				US Patent US10442808 (2019) BindingDB Entry DOI: 10.7270/Q2S75JQ3
					More data for this Ligand-Target Pair
MALT lymphoma-associated translocation (MALT1) (Homo sapiens (Human))	BDBM355951 ((S)-1-(2-chloro-7-(1- methoxy-2- methylpropyl)pyra...) Show SMILES CO[C@@H](C(C)C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H18ClF3N6O2/c1-9(2)16(30-3)15-11(8-24-14-7-13(19)27-28(14)15)26-17(29)25-10-4-5-23-12(6-10)18(20,21)22/h4-9,16H,1-3H3,(H2,23,25,26,29)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair