BDBM356056 (S)-2-fluoro-N-(6-((2- hydroxypropanamido)methyl)-2- phenylpyridin-3-yl)-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 56

SMILES: C[C@H](O)C(=O)NCc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1

InChI Key: InChIKey=QLXJMOGLEFCCFD-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356056   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356056 ((S)-2-fluoro-N-(6-((2- hydroxypropanamido)methyl)-...) Show SMILES C[C@H](O)C(=O)NCc1ccc(NC(=O)c2cc(-c3ccn(C)n3)c(cc2F)C(F)(F)F)c(n1)-c1ccccc1 |r| Show InChI InChI=1S/C27H23F4N5O3/c1-15(37)25(38)32-14-17-8-9-23(24(33-17)16-6-4-3-5-7-16)34-26(39)19-12-18(22-10-11-36(2)35-22)20(13-21(19)28)27(29,30)31/h3-13,15,37H,14H2,1-2H3,(H,32,38)(H,34,39)/t15-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair