BDBM35616 pyrazolo pyrimidine, 5v

SMILES: O=C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1

InChI Key: InChIKey=DPTZAZDLROZORV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 35616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110α/p85α (Homo sapiens (Human))	BDBM35616 (pyrazolo pyrimidine, 5v) Show SMILES O=C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H28N8O2/c37-28(21-2-1-8-29-17-21)35-10-6-22(7-11-35)36-27-23(18-31-36)26(34-12-14-38-15-13-34)32-25(33-27)20-3-4-24-19(16-20)5-9-30-24/h1-5,8-9,16-18,22,30H,6-7,10-15H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.87E+3	n/a	n/a	n/a	n/a	n/a	25
Wyeth Research					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				J Med Chem 52: 7081-9 (2009) Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM35616 (pyrazolo pyrimidine, 5v) Show SMILES O=C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H28N8O2/c37-28(21-2-1-8-29-17-21)35-10-6-22(7-11-35)36-27-23(18-31-36)26(34-12-14-38-15-13-34)32-25(33-27)20-3-4-24-19(16-20)5-9-30-24/h1-5,8-9,16-18,22,30H,6-7,10-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	23
Wyeth Research					Assay Description The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...				J Med Chem 52: 7081-9 (2009) Article DOI: 10.1021/jm9012642 BindingDB Entry DOI: 10.7270/Q2NS0S73
					More data for this Ligand-Target Pair