BDBM356219 2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((2- oxopyrrolidin-1-yl)methyl)-4- phenylpyrimidin-5-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 219

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CCCC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=AARXUGOQUWWYKI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356219 (2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((2- o...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3CCCC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H22F4N6O2/c1-36-11-9-21(35-36)17-12-18(20(28)13-19(17)27(29,30)31)26(39)33-22-14-32-23(15-37-10-5-8-24(37)38)34-25(22)16-6-3-2-4-7-16/h2-4,6-7,9,11-14H,5,8,10,15H2,1H3,(H,33,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
					More data for this Ligand-Target Pair